James H. Hageman
Curriculum Vitae

James H. Hageman
Curriculum Vitae

Education:

Yale University, New Haven, Connecticut. 1969-1971. Microbial Genetics. Postdoctoral Fellow. (Postdoctoral advisor: B. C. Carlton).
University of California, Los Angeles. 1964-1968. Biochemistry. Ph.D.
(Chairman: D. E. Atkinson)
University of Illinois, Urbana, Illinois. 1961-1964. Chemistry. B.S.
University of Bristol, Bristol, England. 1960-1961. Gen. Science, Intermediate B.Sc.

Academic Honors and Appointments:

Professor, Department of Chemistry, University of Colorado Denver 2006- present
Professor, Department of Chemistry, Central Michigan University, 2000- 2006
Professor of Chemistry, New Mexico State University, 1983- 2000
Visiting Faculty, University of Illinois, Urbana, IL (sabbatical leave with R. L. Switzer), 1998
President's Service Award, New Mexico State University, 1989
Donald C. Roush Award for Teaching Excellence, New Mexico State University, 1986 and 1997.
Racial Harmony Award, New Mexico State University, 1996
Intergovernmental Personnel Act Fellow at NIH (sabbatical leave, NINCDS Laboratory Chief: E. Freese) 1978-1979
Assistant (1971-1976) and Associate (1976-1983) Professor (1983- 2000) of Chemistry, New Mexico State University
Lecturer in Biochemistry at Yale University, 1969 and 1970 (two semesters)
American Cancer Society Postdoctoral Fellowship, 1969-1971
NIH Traineeship, UCLA, 1965-1968
Graduate Teaching Assistant, University of California, Los Angeles, 1964-1965
Bachelor of Science in Chemistry with Honors, 1964

Administrative Positions, Experience and activities:

Associate Vice Chancellor for Research, University of Colorado Denver 2008- present
Interim Dean, College of Liberal Arts and Sciences, University of Colorado Denver, 2007-2008
Associate V C for Research and Graduate Studies, University of Colorado Denver 2006-2007

The University of Colorado is a public university which was formed by the merger in 2004 of the University of Colorado at Denver, an urban-serving comprehensive university with 7 doctoral programs and two nationally ranked schools, with the University of Colorado Health Sciences Center, with several nationally ranked departments and schools and numerous members of the National Academy of Medicine. The University of Colorado Denver has 11 schools and colleges and serves over 16,000 undergraduate, graduate and first professional students and 120 post-MD residency students. In 2008 the externally-supported work was just under $400 million, the vast bulk of the funding being at the health science campus. The process of merging is a complex and on-going, which is reflected in the multiple appointments I have held since arriving here about three years ago. Initially I served on the Provost Heckler’s Advisory Team, working closely with him on issues of merging Student Affairs on the two campuses. In 2007 the Provost requested that I serve as the interim dean of the College of Liberal Arts and Sciences, a college with 130 tenure–line faculty members, twenty five direct reports and an annual budget of just over $28 million. In my current role as associate vice chancellor for research, I have worked, especially with faculty on the Downtown campus, to increase scholarly and creative activity and external funding to support them.

As Dean of CLAS, oversaw 25 direct reports and managed a budget over $28 million
As Dean of CLAS, worked closely with departments in the successful hiring of 32 new tenure-track faculty members, including a total of 18% ethnic minority faculty, worked with staff to create two new College seed grant programs and to produce and disseminate the first CLAS research magazine to alumni and friends of UCD
As Dean of CLAS, worked with the Denver Downtown Association to present “tent” meetings during the summer on the downtown mall, a series of general-interest talks given by college faculty
As Dean of CLAS, worked with the CU Foundation officers to make regular contacts with current and potential donors
Was nominated for and completed a year long University of Colorado System “Emerging Leaders” training program
As Dean of the Graduate School, with my health science campus counterpart and at the request of the Chancellor, prepared a plan for merging the two graduate schools (transferring my part time role to a separate, full time graduate dean position)
As Graduate Dean, I chaired and wrote the joint internal and external program review for the College of Engineering and Applied Science at UCD
As AVC for Research, created and currently administer three new campus-wide seed grant programs to enhance faculty scholarly and creative activities and grant writing opportunities
As AVC for Research, created and currently oversee a pool of external grant-writers to assist faculty teams in preparing major and complex grant applications; three grants have been submitted and one was recently funded
As AVC for Research, worked with my staff to transform the downtown grants and contracts office to a research development and education office to serve both campuses; new office made contacts with 4,000 faculty last year
Served as chair and on committee to present an annual UCD-wide student poster session in all areas of scholarly and creative endeavor
Actively participate in a Metro Denver area Sustainability Series of lectures and networking to link to related efforts on the downtown campus
Served as the liaison from the downtown campus to the health science campus advisory team to prepare a successful $53 million NIH-funded clinical translational grant (CTRAC) and currently serve on the CTRAC advisory board
Served in May 2008 on the NSF Institutional Impact Workshop, the findings of which have been published as NSF 09-33 “Impact of Transformative Interdisciplinary Research and Graduate Education on Academic Institutions” (www.igert.org)

Dean, College of Graduate Studies and Vice Provost for Research, Central Michigan University, 2000-2006

Central Michigan University is the fourth largest university in Michigan with over 20,000 students on the Mount Pleasant campus and over 6,000 graduate students, enrolled in both on-campus and distance education programs. When I arrived in 2000, the University had been reclassified by the Carnegie Foundation from a “comprehensive” to a “research intensive” institution. The University offered over 60 graduate programs, including 9 doctoral programs; the office of the Graduate Dean and Vice-Provost for Research had an annual operating budget of over $4.6 million and a staff of 20 people.

Formed a faculty team to create a Senate-approved strategic research plan and implemented many features of the plan
Created and implemented three new internal funding mechanisms to enhance faculty scholarship and to increase applications for external funds – roughly tripling research expenditures in six years
Produced an annual research calendar to promote faculty and student scholarly and creative activities – distributed internally and externally during 2003-2006
Lobbied Michigan congressional delegation with others from CMU to obtain funds from the Army Research Lab to create a national dendrimer center; managed university-company interface for final two years of the grant and an expenditure of $2.7 million in funding; wrote all required federal reports
Created with a staff member CMU’s White Pine Music label (http://wwwwhitepinemusic.com); its activities led the Sphinx Music Organization in Detroit to donate a scholarship in music to CMU
Greatly increased participation in an annual student scholarly and creative poster event to over 350 posters, largely from undergraduates
With other senior administrators at CMU, assisted in forming the CMU Research Corporation (http://www.cmurc.com) and served as its first secretary
Collaborated with three other mid-tier universities in Michigan to write a successful (U-TEAMED) grant to the State for over $1.3 million to foster the transfer of faculty-invented technologies to the marketplace
Established a mechanism, engaged local patent attorneys and encouraged faculty to apply to patent their work; about a dozen disclosures, provisional and full patents were applied for in period 2002-2006
With my associate dean, developed a plan and led a successful campaign with the CMU Board of Trustees to increase graduate teaching assistant funding by $300 and increased minimal gpa requirements for graduate students
Oversaw McNair grant program (managed by Gail Scukanec) to increase the number of graduate students from underserved populations to enter graduate doctoral programs, including submission of a successful 4-year renewal
Initiated and supported efforts which led to the creation of two new doctoral programs – doctorate of physical therapy and an interdisciplinary doctorate of the science of advanced materials

Head, Department of Chemistry and Biochemistry, New Mexico State University, 1992-1998

The Department consisted of 22 faculty members, a secretarial staff of four, a bookkeeper and a stockroom staff of six within the College of Arts and Sciences. As part of a Land Grant university, the Department was responsible for providing general chemistry to a significant proportion of the roughly 14,000 total students as well as an ACS-approved B.S. curriculum in chemistry and biochemistry. As a doctoral granting department, the funding and mentoring of 30-40 graduate students was an important aspect of the department heads duties. The Head was also responsible for oversight of the College glassblowing and instrument and electronics shops (three staff) and managing an annual operating budget of $4.5 million.

Oversaw the initiation and completion of a $20 million dollar addition and renovation to Chemistry and Biochemistry building
Completely re-developed and implemented an effective departmental governance and committee system
Created and issued first bi-annual newsletter to all alumni and friends of the Department – resulting in $150,000 in scholarship gifts over three year period
Fostered development of new teaching methods in freshman chemistry and set up a flexible reward system that recognized top teaching efforts of faculty members
Developed a detailed annual reporting system and “Department at a Glance” summary that took the department from one of the lowest ranked ones in the College to one of the highest
Served for three years as member of the Government Relations Committee of the (national) Council for Chemical Research, lobbying legislators in Washington to support funding in basic chemical sciences
Strongly supported and took part in three funded programs to increase the number of ethnic minority students completing degrees and taking part in research in chemical and biomedical fields; the NIH-funded Bridges to Native American program became a model of effectiveness nationally
Continued to maintain an active teaching and funded research program

Founding Director, Graduate Program in Molecular Biology, NMSU, 1989-1992

From 1987-1989, I led a group of twenty faculty members from five departments and three colleges to prepare all the detailed documentation needed for a proposal to create a new interdisciplinary doctoral program in molecular biology. After the proposal was approved by the Graduate Council and the Provost, it was presented to the State Commission on Higher Education. Once they had approved it, I argued successfully on campus for funds to initiate it, including some partial funding for the Director and an administrative assistant and for some initial graduate student stipends. I was selected by my peers to serve as the founding director. The program has now been successfully in operation for 20 years with a steady stream of doctoral students completing degrees each year

Found office space, hired a half-time administrative assistant and purchased or found office materials to begin the graduate program
Formed faculty committees, developed charges for them and developed promotional materials
Awarded teaching assistantships to new graduate students and developed student-selection and mentoring schemes
Horse-traded with departmental chairs to allow faculty to teach needed courses in exchange for TA support
Set up weekly seminar series for students and faculty
Issued annual reports to the Graduate Dean and Provost on progress of the program

Membership in Professional Societies and Leadership Training:

American Society for Biochemistry and Molecular Biology (elected in 1976)
Society of Sigma XI, UCLA Chapter, Yale Chapter, NMSU Chapter (past president-elect and president)
American Society for Microbiology (since 1970)
American Association for the Advancement of Science (since 1971; elected Fellow, 1990)
American Chemical Society (since 1968; past member of National Examinations Committee - Biochemistry Subcommittee; past treasurer of Rio Grande Section)
American Committee on Proteolysis
Council for Chemical Research (1992- 2006; member of Governmental Relations Committee, 1995-1998)
Colorado University System’s “Emerging Leaders’ Program”, 2006- 2007

RESEARCH EFFORTS
A. Summary of Results

When I joined the faculty at New Mexico State University in the fall of 1971, I focused my research in three areas. The bulk of my work was aimed at trying to describe the molecular details of intracellular protein degradation which occurs in Bacillus subtilis during sporulation and to determine what factors control the specificity and onset of this proteolysis. In this regard my students and I made a number of contributions over the years. Briefly, we: (a) isolated several protease-deficient strains one of which, S-87, has been supplied to a number of academic laboratories and industries (Dow, Genex, Genencor, and Fujisawa) and described by them in publications; (b) shown by 2-D gel analysis and radioisotopic labeling experiments that the relative rates of cellular protein degradation are very high and very extensive but do not correlate with either size or apparent subunit molecular weights of the proteins; (c) have developed a new mild and general method for converting any protein into a chromogenic proteinase substrate; (d) found that proteolysis is probably not the rate limiting step in protein degradation; (e) purified the major intracellular serine proteinase to homogeneity and shown by rocket immunoelectrophoresis that this enzyme is dramatically activated during sporulation (shown by others to be due to loss of an intracellular inhibitor); (f) shown using deletion mutants isolated at Genencor that this proteinase is not essential for proteolysis; (g) have isolated and partially characterized a proteosome-like particle (26S, 2.2 MDa from B. subtilis cells; (h) demonstrated that proteolysis during sporulation is strongly dependent on both energy metabolism and on uptake of calcium ion; (i) purified a calmodulin-like protein from sporulating cells and have now initiated work to clone the gene encoding this calmodulin; (j) have shown with immunogold antibodies that calmodulin is localized at the cell wall-cell membrane region in B. subtilis; (k) showed that benzeneboronic acids selectively inhibit sporulation and prevent the synthesis or activation of the major intracellular proteinase and found that minute quantities of inosine can reverse the inhibitory effects of boronic acids, suggesting that inosine is identical to a previously described sporulation inducer, "sporogen" (work by others in the past five years suggests that boronates may have their effects by forming and alternate autoinducer-2 quorum-sensing structures); (l) showed that the widely used serine protease inhibitor phenylmethylsulfonyl fluoride is far from selective, reacting covalently with at least nine different proteins in cell extracts of B. subtilis as well as rabbit liver; identified and described the first bacterial transglutaminase enzyme, which is currently marketed for food processing purposes by Ajinomoto.

We made contributions of a more general nature as a result of work undertaken in the proteolysis studies. We have: (a) synthesized the first peptide thiobenzyl ester substrate for proteinases, a class of substrates which James Powers has shown are among the very best types for a wide variety of mammalian enzymes including elastase and cathepsin B and are now commercial products; (b) developed the first reproducible assay for collagenase using azocollagen as a substrate; (c) synthesized a fluorescent boronic acid (now marketed by Molecular Probes, Inc..) which can be used to reversibly label cells for flow cytometry; (d) demonstrated that the brown, sporulation-associated pigments of B. subtilis are synthesized non-enzymatically outside the cells and partially characterized one of the four pigments chemically; (e) developed the first single, chemically-defined medium which allows rapid growth and high rates of sporulation of B. subtilis cells (a number of recent publications by others describe results using this medium); and (f) demonstrated that the Michaelis kinetic "constants" from proteinase (and two other enzymes) are a function of both enzyme and substrate concentrations.

A second area of research interest has been in the synthesis of new types of aryl boronic acids and their applications to various problems in biochemistry, especially chromatography. As a result of our observations on the effects of benzeneboronic acid on sporulation, described above), Dr. Glenn Kuehn and I developed a high-capacity polyacrylamide-boronic acid gel which we showed could be used in a very efficient assay for adenylate cyclase. We were the first to show that such diol-binding supports could be used to carry out "exchangeable-ligand chromatography" of enzymes. (In this the enzyme is bound to a diol-containing cofactor, such as UTP, which is covalently but reversibly bound to the boronic acid.) The gel which we developed is currently marketed by Bio-Rad Corp. as Affi-gel P-601. In addition my students and I have synthesized a diboronic acid which acts, in a sense, like a synthetic lectin in that it can agglutinate red blood cells. Most recently we have synthesized and tested a number of new boronic acids which have lower pK's than the commercially available ones and will extend their range of utility to solutions near neutrality; we have obtained an x-ray crystal structure for one of these and have developed a very good new spectral difference method for measuring ionization and diol binding constants for these new compounds. Finally, we designed synthetic methods for boronic acids which we believe will be capable of resolving certain types of stereoisomers.

My third area of research was aimed at domesticating tumbleweed, a plant which would be of economic use in semi-arid lands; this effort, although initiated by me in 1973, was done in close collaboration with Dr. James Fowler in the Department of Agronomy and Horticulture at NMSU. The plants we investigated are of the genus Salsola, commonly known as Russian thistles or tumbleweeds. Our pioneering work established that these plants: (a) are of high nutritional quality based on proximal chemical analysis; (b) can produce as much dry matter per year as established forage species such as alfalfa; (c) are 2-3 times more efficient in their use of water than other common forage species; (d) produce few if any deleterious compounds; and (e) increase in dry matter production when irrigated with saline water (are true halophytes). We believe the selection program we started shows great promise for leading to a new crop for semi-arid agriculture. Some of our work was summarized in the May, 1988, issue of Smithsonian magazine in an article by Jack Fincher and in the February, 1991, issue of Discover magazine.

A. Publications

1.   L. Klungsyr, J. H. Hageman, L. Fall and D. E. Atkinson. Interaction between Energy Charge and Product Feedback in Regulation of Biosynthetic Enzymes Aspartokinase, Phosphoribosyladenosine Triphosphate, and Phosphoribosyl Pyrophosphate Synthetase. Biochemistry 7, 4035-4040 (1968).
2.   J. H. Hageman and B. C. Carlton. An Enzymatic and Immunological Comparison of Two Proteases from a Transformable Bacillus subtilis with the "Subtilisins". Arch. Biochem. Biophys. 139, 67-69 (1970).
3.   J. H. Hageman and B. C. Carlton. Effects of Mutational Loss of Specific Intracellular Proteases on Sporulation of Bacillus subtilis. J. Bacteriol. 114, 612-617 (1973).
4.   D. A. Farmer and J. H. Hageman. Use of N-Benzoyl-L. Tyrosine Tiobenzyl Ester as a Protease Substrate. J. Biol. Chem. 250, 7366-7371 (1975).
5.   G. Geele, E. Garrett and J. H. Hageman. Effect of Benzene Boronic Acids on Sporulation and on Production of Enzymes in Bacillus subtilis Cells. Spores VI, P. Gerhardt, R. N. Costilow and H. L. Sadoff, eds. Am. Soc. Micro. 391-396 (1975).
6.   D. A. Farmer, J. L. Fowler and J. H. Hageman. Evaluation of Protein and Nutritive Fiber Content of Cultivated Russian Thistle. Agron. J. 68, 691 (1976).
7.   J. H. Hageman and J. L. Fowler. Protein Production by Russian Thistle: Effects of Water and Nitrogen on Protein Yields. WRRI Technical Completion Report No. 85, 1-17 (1977).
8.   D. D. Davis, G. K. King, K. L. Stevenson, E. R. Birnbaum and J. H. Hageman. Photoredox Reactions of Metal Ions for Photochemical Solar Energy Conversion. J. Solid State Chem. 22, 63-70 (1977).
9.   J. H. Hageman and G. D. Kuehn. Assay of Adenylate Cyclase by Use of Polyacrylamide-Boronate Gel Columns. Anal. Biochem. 80, 547-554 (1978).
10.    K. Davis-Mancini, I. P. Lopez, and J. H. Hageman. Benzeneboronic Acid Selectivity Inhibits Sporulation. J. Bacteriol. 136, 625-630 (1978).
11.    J. H. Hageman, J. L. Fowler, and D. A. Schafer. Nitrogen Fertilization of Irrigated Russian-thistle Forage. II. Some Nutritional Qualities. Agro. J. 70I:992-995 (1978).
12.    J. L. Fowler and J. H. Hageman. Nitrogen Fertilization of irrigated Russian-thistle Forage. I. Yield and Water Use Efficiency. Agr. J. 70:898-992 (1978).
13.    J. H. Hageman. The Structure of Acetyl Lipoic Acid. Trends in Biochemical Sciences. 4, N188 (1979).
14.    V. Sekar and J. H. Hageman. Specificity of the Serine Protease Inhibitor, Phenylmethylsulfonyl Fluoride. Biochem. Biophys. Res. Comm. 89, 474-478 (1979).
15.    R. R. Maestas, J. R. Prieto, G. D. Kuehn and J. H. Hageman. Polyacrylamide-Boronate Beads Saturated with Biomolecules: A New General Support for Affinity Chromatography of Enzymes. J. Chromatog. 189, 225-231 (1980).
16.    T. J. Burnett, H. C. Peebles and J. H. Hageman. Synthesis of a Fluorescent Boronic Acid which Reversibly Binds to Cell Walls and a Diboronic Acid which Agglutinates Erythrocytes. Biochem. Biophys. Res. Comm., 96, 157-162 (1980).
17.    J. W. Fowler and J. H. Hageman. Russian-thistle, a Potential Forage for Acid Lands p. 430-433 in Arid Land Plant Resources, J. R. Goodin and D. Nothington, eds. Texas Tech. Univ. Lubbock Proceedings of International Arid Lands Conference on Plant Resources, July 1979 (1980).
18.    V. Sekar, S. P. Wilson and J. H. Hageman. Induction of Sporulation in Bacillus subtilis by Nucleosides: Inosine Appears to be Sporogen. J. Bacteriol., 145, 489-493 (1981).
19.    C. A. Roitsch and J. H. Hageman. Bacillopeptidase F: Two Forms of a Glycoprotein Serine Protease from Bacillus subtilis 168. J. Bacteriol. 155, 145-152 (1983).
20.    T. A. Barnett and J. H. Hageman. Characterization of a Brown Pigment from Bacillus subtilis. Cultures. Can. J. Microbiol. 29, 309-315 (1983).
21.    T. A. Barnett, D. Valenzuela, S. Riner and J. H. Hageman. Production by Bacillus subtilis of Brown Sporulation Associated Pigments. Can. J. Microbiol. 29, 96-101 (1983).
22.    R. Chavira, Jr., T. J. Burnett and J. H. Hageman. Assaying Proteinases with Azocollagen. Analytical Biochem. 136, 446-450 (1984).
23.    J. M. Dubach and J. H. Hageman. Kinetics of Cytoplasmic Aspartate Aminotransferase from Three Genotypes of the Deer Mouse (Peromyscus maniculatus). Comp. Biochem. Physiol. 78B, 691-699 (1984).
24.    J. H. Hageman, G. W. Shankweiler, P. R. Wall, K. Franich, G. W. McCowan, S. M. Cauble, J. Grajeda, and C. Quiñones. Single, Chemically Defined Sporulation Medium for Bacillus subtilis: Growth, Sporulation, and Extracellular Protease Production. J. Bacteriol. 160, 438-441 (1984).
25.    J. L. Fowler, J. H. Hageman and M. Suzukida. Evaluation of the Salinity Tolerance of Russian Thistle to Determine its Potential for Forage production using saline irrigation water. WRRI Technical Completion. NMSU Report NO. 198, 1-50 (1985).
26.    M. S. Daugherty, M. L. Galyean, D. M. Hallford and J. H. Hageman. Vitamin B12 and Monensin Effects on Performance, Liver and Serum Vitamin B12 Concentration and Activity of Propionate Metabolizing Hepatic Enzymes in Feedlot Lambs. J. Ani.. Sci. 62, 452-463 (1986).
27.    I. J. Fry, L. Villa, G. D. Kuehn and J. H. Hageman. Calmodulin-like Protein from Bacillus subtilis. Biochem. Biophys. Res. Comm. 134, 212-217 (1986).
28.    T. J. Burnett, G. W. Shankweiler and J. H. Hageman. Activation of Intracellular Serine Proteinase in Bacillus subtilis Cells During Sporulation. J. Bacteriol. 165, 139-145 (1986).
29.    V. Sekar, J. H. Hageman. Protein Turnover and Proteolysis during Sporulation of Bacillus subtilis. Folia Microbiol. 32, 465-480 (1987).
30.    J. H. Hageman, J. L. Fowler, M. Suzukida, V. Salas and R. LeCapitan. Analysis of Russian thistle (Salsola species) Selections for Factors Affecting Forage Nutritional Value. J. Range Manag. 41, 155-158 (1988).
31.    J. L. Fowler, J. H. Hageman, M. Suzukida and H. Assadian. Evaluation of Salinity Tolerance of Russian-Thistle, a Potential Forage Crop. Agron. J. 80, 250-258 (1988).
32.    S. Soundaramani, M. Badawi, C. Montaño-Kohlrust and J. H. Hageman. Boronic Acids for Affinity Chromatography: Spectral Methods for Determination of Ionization and Diol-binding Constants. Analytical Biochem. 178, 125-134 (1989).
33.    J. H. Hageman, review of "Proteins. A Theoretical Perspective of Dynamics, Structure, and Thermodynamics" by C. L. Brooks III, M. Karplus and B M. Petit. J. Am. Chem. Soc. III, 9140 (1989).
34.    M. B.. O'Hara and J. H. Hageman. Energy and Calcium Ion Dependence during Sporulation of Bacillus subtilis Cells. J. Bacteriol. 172, 4161-4170 (1990).
35.    I. J. Fry, M. Becker-Hapak and J. H. Hageman. Purification and Properties of an Intracellular Calmodulin-like Protein from Bacillus subtilis Cells. J. Bacteriol. 173, 2506-2513 (1991).
36.    J. H. Hageman and G. D. Kuehn. Boronic Acid Matrices for the Affinity Chromatography of Glycoproteins and Enzymes pp. 45-71 In Methods in Molecular Biology, Vol. 11: Practical Protein Chromatography (A. Kenney and S. Fowell, eds) Humana Press, Clifton, N. J., (1992).
37.    J. L. Fowler, ,J. H. Hageman, K. J. Moore, M. Suzukida, H. Assadian, and M. Valenzuela. Salinity Effects on Forage Quality of Russian Thistle. J. Range Manag. 45, 559-563 (1992).
38.    S. Soundaramani, E. N. Duesler and J. H. Hageman. Structure of 4-Carboxy-2-nitrobenzeneboronic Acid. Acta Cryst. C49, 690-693 (1993).
39.     V. Norris...J. H. Hageman...C. Yanofsky (74 authors). Cell Cycle Control: Procaryotic Solutions to Eucaryotic Problems? J. Theoret. Biol. 168, 227-230 (1994).

N. G. Gallegos, J. Jun and J. H. Hageman. Preparation of General Proteinase Substrates using 3,5-Dinitrosalicylaldehyde. J. Biophys. Biochem. Methods 33, 31-41 (1996)
J. H. Hageman. Bacillopeptidase F. In Handbook of Proteolytic Enzymes (A. J. Barrett, N. D. Rawlings, J. F. Woessner, eds.) pp. 301-303 (1998), Academic Press, NY
J. H. Hageman and R. L. Switzer, ISP-4 and CWBP52 are Proteins Encoded by the Same Gene in Bacillus subtilis. Microbiology 145, 281 (1999)
D. D. Dominguez, H. Adams and J. H. Hageman, Immunocytochemical Localization of a Calmodulinlike Protein in Bacillus subtilis Cells. J. Bacteriol. 181, pp. 4605-4610 (1999)
J. H. Hageman, Active Use of Molecular Models in Teaching Biochemistry. Michigan Academician 34, p. 11 (2002)
J. H. Hageman. Bacillopeptidase F. In Handbook of Proteolytic Enzymes (A. J. Barrett, N. D. Rawlings, L. Tickner, J. F. Woessner, eds.) pp. 1795-1796 (2004), Academic Press, NY
J. Hageman, The Use of Molecular Models in Active Teaching of Biochemistry (accepted by J. Chem. Education 7/2009)

B. Current Manuscripts (at various stages )

    1. J. Jun and J. H. Hageman. Protein Degradation in Strains of Bacillus subtilis Multiply Deficient in Proteinases. (to be submitted to J. Bacteriol.)
2.   A. Mbuyi-Kalala, J. Jun and J. H. Hageman. The Variability of the Michaelian Constants with Substrate and Enzyme Concentrations: b-Galactosidase, Subtilisin, Glucosidase, and Akaline Phosphatase.
3.   G. W. Shankweiler and J. H. Hageman. Characterization of a proteoglycan protease excreted by Bacillus subtilis cells during sporulation (manuscript in preparation for J. Bacteriol.)

D. Presentations and Published Abstracts: National and International Meetings

1.   J. H. Hageman and B. C. Carlton. Attempt to Determine Proteases Involved in Bacterial Sporulation. Fifth International Conference on Spores. October 8-12, 1971, Madison, Wisc.
2.   G. Geele, E. Garret and J. H. Hageman. Effect of Phenyboronic Acids on Sporulation and Enzyme Levels in Bacillus subtilis. Sixth International Spores Conference. October 10-13, East Lansing, Mich.
3.   L. Lara, D. Farmer and J. H. Hageman. Kinetics of Hydrolysis of N-Benzoyl-L-Tyrosine Thiobenzyl Ester by µ-Chymotrypsin. FASEB Meeting, April, 1974, Atlantic City.
4.   J. L. Fowler and J. H. Hageman. Nutritional Qualities of Russian Thistle. American Agronomy Meetings, November 29, 1976, Houston, Texas.
5.   C. A. Roitsch and J. H. Hageman. Low Molecular Weight Subunits of the Acidic Extracellular Esterase-Protease of Bacillus subtilis. Fed. Proc. 35, 1474, 1976.
6.   J. H. Hageman and G. D. Kuehn, Affinity Chromatography with a Boronic Acid Derivative. A General Method Applied to a Simplified Adenylate Cyclase Assay. Fed. Proc. 35, 1711, 1976.
7.   R. R. Maestas and J. H. Hageman. Boronate Gels for Affinity Chromatography: Binding of Biomolecules to Gels. Second Annual Western States Minority Biomedical Support Symposium, August 17-19, 1977, La Jolla, California.
8.   C. A. Roitsch and J. H. Hageman. Some Physico-Chemical Properties of Bacillopeptidase F from Bacillus subtilis. VIIth International Spores Conference, October 5-8, 1977, Madison, Wisc.
9.   J. L. Fowler and J. H. Hageman. Russian-thistle, A Potential Forage for Arid Lands. Proc. International Arid Lands Conference on Plant Resources. Texas Tech University Press, 1978.
10.    J. H. Hageman, S. P. Wilson and V. Sekar. Induction of Sporulation in Bacillus subtilis: Is Inosine Sporogen? Fed. Proc. 37, 1612, 1978.
11.    J. H. Hageman, T. J. Burnett and H. Peebles. Synthesis of Boronic Acids Which Bind to Glycoproteins and Agglutinate Red Blood Cells. XIth International Congress of Biochemistry, July 8-13, 1979, Toronto, Canada.
12.    V. Sekar and J. H. Hageman. Protein Degradation and Turnover in Sporulating Bacillus subtilis. Fed. Proc. 39, 1681, 1980.
13.    J. H. Hageman. Presented invited lecture entitled "Role of Proteases in Bacterial Sporulation" at 80th Annual Meeting of Am. Soc. Microbiol. May 11-16, 1980. Miami Beach, Florida.
14.    T. J. Burnett, J. Stoll and J. H. Hageman. Hydrolysis of Carbobenzyloxy-L-glutamyl p-nitroanilide and Carboxybenzyloxy-L-glutaminyl-p-nitroanilide by Subtilisin BPN' and by Extracts of Sporulating Bacillus subtilis. Fed. Proc. 40, 1789 (Abst. # 1433) 1981.
15.    M. Badawi and J. H. Hageman. Synthesis of Boronic Acids and Preparation of Carbohydrate Affinity Supports. Fed. Proc. 41, 876 (Abst. # 3545) 1982.
16.    T. J. Burnett and J. H. Hageman. Apparent Activation of Intracellular Serine Protease of Bacillus subtilis during Sporulation. Fed. Proc. 42, 1950 1983.
17.    J. H. Hageman. Protein Degradation in Bacillus subtilis during Growth and Sporulation in a Chemically Defined Medium. IX International Spores Conference, Asilomar, California, September 3-6, 1984.
18.    G. W. Shankweiler, T. J. Burnett and J. H. Hageman. Protein Degradation and Protease Levels in Bacillus subtilis Sporulating in a Defined Sporulation Medium. Fed. Proc. 43, 1857, 1984.
19.    I. F. Fry, L. Villa, G. D. Kuehn and J. H. Hageman. Calmodulin-like Protein from Bacillus subtilis: Purification and Properties. Fed. Proc. 44, 1776, 1985.
20.    M. B. O'Hara and J. H. Hageman. Regulation of Proteolysis in Bacillus subtilis. 14th Annual MBRS Symposium, New Orleans, April 16-20, 1986.
21.    A. Mbuyi-Kalala and J. H. Hageman. Variability of Michaelian Constants (Km and kcat) of Subtilisin as a Function of Substrate and Enzyme Concentrations. 72nd Annual Meeting FASEB J. 2, A1776, 1988.

22.    A. Mbuyi-Kalala and J. H. Hageman. Fallacy of the Stationary Principle in Enzyme and Chemical Kinetics. Am. Assoc. Adv. Sci. Annual Meeting, San Francisco, Jan. 14-19, 1989.
23.    A. Mbuyi-Kalala and J. H. Hageman. Derivation of an Exact Solution of the Brown/Henri/Michaelis-Menten Kinetic Model. 73rd Annual Meeting of FASEB. J. Cell. Biol. 107, 836a, 1989.
24.    A. Mbuyi-Kalala and J. H. Hageman. Simulations of the Michaelis-Menten Equation and the Exact Initial Rate Solution of the Michaelis-Menten Model. 81st Annual Meeting ASBMB, New Orleans, June 3-7, 1990. FASEB J. 4, A2301, 1990.
25.    M.V. Ramanujam and J. H. Hageman. Intracellular Transglutaminase (E.C. 2.3.2.13) in a Procaryote: Evidence from Vegetative and Sporulating Cells of Bacillus subtilis 168. 81st Annual Meeting ASBMB, New Orleans, June 3-7, 1990. FASEB J. 4, A2321, 1990.
26.    S. A. Critz and J. H. Hageman. A Calmodulin-Like Protein from Bacillus subtilis Cells. Eleventh International Spores Conference. Woods Hole, MA, May 9-13,, 1992.
27.    N. G. Gallegos and J. H. Hageman. Preparation of a General Proteinase Substrate Using 3.5-Dinitrosalicylaldehyde. SACNAS Annual Conference,, Albuquerque, NM. Jan. 14-18, 1993.
28.    B. A. Martinez, Sue A. Critz and J. H. Hageman. Improved Purification Method for a Calmodulin-like Protein from Bacillus subtilis Cells. 1993 NIGMS Minority Programs Symposium. Atlanta, GA, Nov. 3-6, 1993.
29.    M. de la Peña and J. H. Hageman. Protein Degradation and Catalase Activity in Bacillus subtilis during Sporulation. 84th Annual Meeting of ASBMB, San Diego, May 30-June 3, 1993. FASEB J. 7, A1188, 1993.
30.    J. Jun and J. H. Hageman. Construction and Properties of a Bacillus subtilis Strain Deficient in Seven Proteases. 93rd Annual Meeting, Am. Soc. Microbiol., Las Vegas, NV, May 23-27, 1994.
31.   D. Dominguez and J. H. Hageman. Immunocytochemical Localization of a Calmodulin-like Protein in Bacillus subtilis Cells. Am. Soc. Biochem. Molec. Biol./Am. Chem. Soc. Joint Meeting, San Francisco, CA, May 21-25, 1995.
32.    K. C. Brooks, G. A. Eiceman and J. H. Hageman. Restructuring the Prep Chem Course at NMSU. 209th National Meeting of the Am. Chem. Soc. Anaheim, CA, April 2-6, 1995.
33.   H. Dominguez, C. Rivas and J. H. Hageman. Sporulation and Intracellular Protein Degradation of a Hydrogen-Peroxide Resistant Mutant of Bacillus subtilis. 1995 NIGMS Minority Programs Symposium, Washington, DC, Oct. 11-15, 1995.
34.   M. Begay and J. H. Hageman. Construction of Bacillus subtilis 3036 Genomic Library. 1995 NIGMS Minority Programs Symposium, Washington, DC, Oct. 11-15, 1995.
35.   J. Jun and J. H. Hageman. Purification and Characterization of a 26S Proteosome from Bacillus subtilis. Am. Soc. Biochem. Molec. Biol./Am. Chem. Soc. Joint Meeting, San Francisco, CA, May 21-25, 1995.
36.   J. Jun and J. H. Hageman. Studies on a Proteosome Isolated from Bacillus subtilis Cells. 12th International Spores Conference. Madison, WI. June 5-8, 1996
37.   R. L’Hommedieu, J. Hageman, S. Burgess and M. Roy. “University Audio Recording in the Digital Age: Managing Rights and Permissions, Resources and Institutional Priorities” (panel presentation and discussion), 79th Ann. Meeting of National Association of Schools of Music, Seattle, WA, Nov. 22-25, 2003. By request this material was also presented at the Forty-ninth Colleger Music Society National Conference in San Antonio, TX September 16, 2006.
38.   S. Garrison, C. Riordan and J.H. Hageman, "From Curriculum Vitae To Academic
      Business   Intelligence: Building an Intellectual Capital Repository," 2005 EDUCAUSE
       Midwest Regional Conference in Chicago, Illinois. March 21, 2005.
39.   J. Hageman and W. Weiner Reponses to the Keynote by Carole Beere on “The Future of the Graduate School” at the 63rd Annual Midwestern Association of Graduate School Meeting, Indianapolis, IN, April 11-13, 2007.

E. Research-Linked Grants

YEAR(S)	SOURCE	SUBJECT	AWARD
1972-1975	ACS-PRF	Sporulation Pigment of B. subtilis	$7,500
1973-1976	NIH	Role of Proteases in Sporulation	$49,508
1973-1975	NSF	Role of Proteases in Sporulation-Awarded but not accepted because of duplicated NIH Grant	---
1973	NMSU, A&S	Starter grant for H2 production	$2,500
1974	State of New Mexico	Photolytic Decomposition of Water	$24,450
1975	Water Resources1 Research Institute	Protein Quality of Russian Thistle	$14,899
1976	Water Resources2 Res. Institute	Water Use Efficiency of Russian Thistle	$17,000
1976-1979	NIH	Protease in Protein Turnover	$110,275
1979-1981	NIH	Protein Turnover in Bacillus subtilis	$84,126
1979-1981	NIH	Boronic Acid Probes Of Glycoproteins	$80,559
1980-1982	NSF1	Crambe for Oil Production	$99,000/2yr
1982	Bio-Rad Corporation	Synthesis of Boronic Acid Derivative	$2,000
1983-1985	American Cancer Society	Inhibitors of Collagenase	$47,000/2yr
1983-1984	NMSU, Plant Genetic Engineering Lab1	Screening Russian Thistle Plants	$37,000
1985-1986	NMSU Plant Genetic Engineering Lab1	Screening Russian Thistle Plants	$8,000
1984-1985	New Mexico Water Resources Institute	Salinity Tolerance in Russian Thistle	$25,871
1987-1989	USDA	Role of Calcium Binding Proteins in Spore Formation and Germination	$32,500
1989	NIH	Small Instruments Grant	$7,300
1986-1990	NIH	Regulation of Proteolysis in Bacillus subtilis Cell	$260,69
1995-1996	NIH	Predoctoral Fellowship (to D. Dominguez)	$15,197
2003	Mich. EDC	Creation of Joint Four-University Tech Transfer Office in Michigan	$1,260,000
		TOTAL	$1,950,775

From 1973 through 1996, I was a participant in successful group efforts which have led to obtaining grants (from NSF or NIH) for the purchase of: a diode array spectrometer, a Gilford Response spectrometer, a Packard Liquid Scintillation spectrometer, a New Brunswick 75 L fermentor and cell harvesters, two Pharmacia FPLC units, a PROPHET Sun computer facility, a Hitachi electron microscope, a 400 MHz Varian nmr, an automated DNA sequenator and a phosphoimager. The 2003 Michigan Economic Development grant was co-written by four research VP’s led by Michigan Technological University. From 2004-2006, I served as the program director for an Army Research Lab earmark for about $2.5 million which was awarded to Central Michigan University. I served as the PI on a multi-million dollar grant to oversee flow-through to the National Renewable Energy Lab from the DoE to support the National Science Bowl and summer internships at NREL (FY 2008 and 2009)

TEACHING ACTIVITIES

A. Formal Courses and Seminars Taught

During my tenure at New Mexico State I have prepared lectures for and taught 10 different courses: I have also been responsible for graduate and undergraduate research seminars and discussions on numerous occasions.

COURSE	# OF SEMESTERS TAUGHT
Freshman chemistry	7
Introductory Organic Chemistry	1
Biochemistry for allied sciences	7
Introductory biochemistry	21
Introductory biochemistry laboratory	19
Chemistry honors course	1
Graduate Biochemistry I	7
Graduate Biochemistry laboratory	2
Graduate Biochemistry II	5
Proteins and enzymes	7
Nucleic acid biochemistry	3
Molecular Biochemistry and Genetics	3
Graduate student seminar	7
Senior thesis research	23
Seminar in Biochemistry and Molecular Biology	8
Plant Biochemistry	2
Senior seminar (capstone course)	2

B. Graduate Students Who Worked on a Thesis or Dissertation With Me

STUDENT	COMPLETED	CURRENT POSITION
Steve Riner	M.S	Public Health Officer, Minneapolis
Ted Oakes	Research Work Only	M.D.,(UNM)
Terry Barnett	Ph.D	Prof. Chem./Southwestern College, Winfield, KS
Carolyn Roitsch	Ph.D	Research Director Transgene Strasbourg, Frace
Joseph Wilson	M.S.	Practicing Medicine, Lubbock Texas MA
V. Sekar	Ph.D	Associate Professor, Madurai University, India
Susan Smith	Research Work Only	High School Teacher, Tucson
Michael Vigil	Research Work Only	M.D., (UNM) in Las Cruces
Thomas Burnett	Ph.D	Lab Head, Eli Lilly, Indianapolis, IN
Richard Selinfreund	M.S research	Vice-Pres., Lion Imaging, Conn.
Gary Shankweiler	Ph.D	Instr. Cal State Long Beach
William McDougall	Interdisciplinary M.S.	University of Michigan
S. Soundaramani	M.S.	Enzon, Inc. (NJ)
Ilona Fry	Ph.D	Research Scientist, Edgewood REsearch, Develpment & Eng., Maryland
Monica O'Hara	M.S.	DuPont Corp., IL
Linh Vu	M.S.	Monsanto (St. Louis)
M.V. Ramanujam	M.S.	Researcher, Regeneron Pharmaceutical
Meei-Jyuan Guo	M.S.	Biotech, Taiwan
Marcia Skaar	M.S.	Instructor ,NMSU, Alamogordo
Mario De la Pena	Ph.D	NIH Research Associate
Jeongwon Jun	Ph.D.	Visiting Asst. Prof., NMSU
Delfina Dominguez	Ph.D.	Asst. Prof., U.T., El Paso, TX
Sue Critz	Doctoral sudent	Flight instructor
Wyatt Allen	M.S. Student	Thesis with Lammers

C. Undergraduate Students Who Worked in my Laboratory

I have supervised undergraduate research for 28 students who worked on senior thesis projects or in other research capacity in my laboratory.

In addition to these students I have directed the work of a further 29 students who were participants in the NIH/DRR-funded Minority Biomedical Research Support, the Minority Access to Research Careers or the Bridges to Native American Community Colleges programs.

D. Grants Supporting Teaching and Minority Student Programs

YEARS	SOURCE	SUBJECT	AMOUNT AWARDED
1974	NSF	Design of an Intergrated Senior Chemistry Lab	$1,200
1973-1993	NIH/MBRS	Minority Biomedical Research Support Program-Topics Related to Protein Degradation in Bacillus subilis	$424,181
1986-1993	NIH	High School Apprentice Program	$18,000
1993- 2000		Bridges program/Native American Students	$24, 000
1982,1984,1996	NIH	Minority access to Research Career Grant	$26,000
		TOTAL	$488,381

E. Other Graduate Student Thesis and Dissertation Committees

Within the Department of Chemistry I have served on committees for 54 students, in addition to those for my own students. Outside the department I have served in various capacities on the committees of 56 students.

IV. PROFESSIONAL AND ACADEMIC EFFORTS

A. Published Book Reviews

1.         Enzymic Catalysis by J. Westley, Harper and Rowe, N.Y. 1969, reviewed in Yale Journal of Biology and Medicine in 1970.
2.         Biochemistry, 2nd ed. by A. L. Lehninger, Worth, reviewed in J. Chem. Educ. 54, A386-A388 (1977).
3.         Introduction to Biochemistry by Routh, Saunders, reviewed in J. Chem. Educ. 56 A144 (1979).
4.         Proteins, A Theoretical Perspective of Dynamics, Structure and Thermodynamics by C. L. Brooks III, M. Karplus and B. M. Pettitt, reviewed in J. Am. Chem. Soc. III, 9140

B. Editing and Reviewing

1.         Since 1991 served as member of the National Science Foundation Graduate Fellowship Panel (Biochemistry and Molecular Biology).
2.         Served as major reviewer of Lehninger's Principles of Biochemistry (1982) and as a reviewer for Lehninger, Nelson and Cox 2nd edition (1993).
3.         Reviewed several chapters in Stryer's Biochemistry (3rd edition).
4.         Reviewed several chapters in Starr and Taggart's Biology (3rd edition).
5.         Since 1979, served as reviewer of 16 manuscripts in microbiological and biochemical journals.
6.         Since 1981, reviewed 14 grant proposals from various government agencies.
7.         In 1989, reviewed study guide by Lindquist for biochemistry text of Rawn

C. Work in Professional Societies

1.       Served on the national Council for Chemical Research/Government Relations Committee, which involves lobbying members of Congress with respect to the needs for research spending in the chemical sciences from 1995-1998 and on NICHE committee 2001-2005.
2.         Served on the NSF Graduate Fellowship Committee, 1992-1995
3.         Served on Education Committee of American Chemical Society to prepare 1977, 1982 and 1992 national
standardized Exams in Biochemistry.
4.         Served in 1975 and 1976 as President-elect and president of NMSU chapter Society of Sigma Xi.
5.         Listed in ACS Affiliates Speakers Tours Book.
6.         Listed in FASEB Visiting Scientist for Minority Institution Program. (lectures at Lehman College).
7.         Listed as speaker in New Mexico Academy of Sciences Twenty-Eighth Visiting Scientist Program (1988-1993)
8.         Served on responding panel for the Midwestern Association of Graduate Schools annual meeting (2007)
9.         Served on NSF workshop panel to prepare report on efficacy of interdisciplinary doctoral programs such as IGERT (2008)

D. Sabbatical Leaves

For the academic year 1978-1979 (11 months), I applied for and obtained an Intergovernmental Personnel Act Fellowship to work in the Laboratory of Molecular Biology at NIH with the chief of that laboratory, Dr. Ernst Freese. While in Bethesda, I worked on determining guanine and adenine nucleotide levels during sporulation of Bacillus subtilis. For 6 months (June – December, 1998) I worked on problems in pyrimidine metabolism, including molecular genetic approaches, in the laboratory of Robert L. Switzer at the University of Illinois, Urbana, IL.

James H. Hageman Curriculum Vitae

Administrative Positions, Experience and activities:

Dean, College of Graduate Studies and Vice Provost for Research, Central Michigan University, 2000-2006

James H. Hageman
Curriculum Vitae