THIRD INTERNATIONAL CONFERENCE ON

ARSENIC EXPOSURE AND HEALTH EFFECTS

PROGRAM

SAN DIEGO, CALIFORNIA

JULY 12-15, 1998

HOLIDAY INN ON THE BAY

CONFERENCE CO-CHAIRS

WILLARD R. CHAPPELL, Ph.D.

UNIVERSITY OF COLORADO DENVER

CHARLES O. ABERNATHY, Ph.D.

U.S. ENIVIRONMENTAL PROTECTION AGENCY

REBECCA L. CALDERON, Ph.D.

U.S. ENVIRONMENTAL PROTECTION AGENCY

SPONSORS

Society of Environmental Geochemistry and Health (SEGH)

University of Colorado Denver (UCD)

Agency for Toxic Substances and Disease Registry (ATSDR)

U. S. Environmental Protection Agency (US EPA)

Atlantic Richfield Company (ARCO)

Electric Power Research Institute (EPRI)

International Council on Metals in the Environment (ICME)

Elf Atochem

Environmental Arsenic Council (EARC)

5:00-7:00 WELCOMING RECEPTION and REGISTRATION (Poolside)

Mexican Hors d'oeuvres and a Cash Bar

Presentations will be held in Pacific Rooms B/C.

7:00-8:00 Registration and Continental Breakfast (Pacific Foyer)

8:00-8:15 Introductory Remarks

8:15-8:30 Preliminary Remarks

8:30-9:45 Occurrence and Exposure Chair: Cragin, David

8:30-8:45AM Thornton, Iain ARSENIC IN THE GLOBAL ENVIRONMENT: LOOKING TOWARDS THE MILLENNIUM

8:45-9:00AM Welch, Alan ARSENIC IN GROUND WATER OF THE UNITED STATES

9:00-9:15AM Yager, Janice AIRBORNE EXPOSURE TO ARSENIC OCCURRING IN COAL FLY ASH

9:15-9:30AM Buchet, Jean CONSISTENCY AMONG BIOMARKERS FOR THE ASSESSMENT OF EXPOSURE TO INORGANIC ARSENIC: A LITERATURE REVIEW

9:30-9:45AM Hindmarsh, J.T. HAIR ARSENIC AS AN INDEX OF TOXICITY

9:45-10:00 Break

10:00-11:30AM Food and Other Exposure Media Chair: Yager, Janice

10:00-10:15AM Crecelius, Eric METHODS FOR THE ANALYSIS OF ARSENIC SPECIATION IN SEAFOOD FROM COOK INLET ALASKA

10:15-10:30AM Grissom, R.E. ESTIMATING TOTAL ARSENIC (As) EXPOSURE AT SITES IN THE U.S.

10:30-10:45AM Irgolic, Kurt ARSENIC COMPOUNDS IN TERRESTRIAL AND MARINE BIOTA

10:45-11:00AM Le, X. Chris METABOLISM OF ARSENOSUGARS PRESENT IN SEAFOOD & MARINE BIOTA

11:00-11:15AM Schoof, Rosalind A MARKET BASKET SURVEY OF INORGANIC ARSENIC IN FOOD

11:15-11:30AM Menzel, Dan A PROBABILISTIC ESTIMATE OF THE US ARSENIC EXPOSURE

11:30-12:00 Panel Discussion on Occurrence and Exposure Chair: Cragin, David

12:00-1:00 Lunch-Buffet in Hotel

1:00-2:30 Poster Session I

2:30-5:00 Health Effects --Non-Cancer Chair: Rebecca Calderon

2:30-3:00 Chien-Jen Chen EMERGING EPIDEMICS OF ARSENIASIS IN ASIA

3:00-3:15 Sun Gui Fan THE PRESENT SITUATION OF CHRONIC ARSENISM AND RESEARCH IN CHINA

3:15-3:30 Ma, Heng Z. ARSENIC EXPOSURE AND HEALTH EFFECTS IN INNER MONGOLIA, CHINA

3:30-3:45 Break

3:45-4:00 Lewis, Denise DRINKING WATER ARSENIC: THE MILLARD COUNTY, UTAH MORTALITY STUDY

4:00-4:15 Siripitayakunkit, U. ASSOCIATION BETWEEN CHRONIC ARSENIC EXPOSURE AND CHILDREN'S INTELLIGENCE IN THAILAND

4:15-4:30 Hopenhayn-Rich, C. REPRODUCTIVE AND DEVELOPMENTAL EFFECTS ASSOCIATED WITH CHRONIC ARSENIC EXPOSURE

4:30-4:45 Chakraborti, Dipankar ARSENIC GROUNDWATER CONTAMINATION AND THE SUFFERING OF PEOPLE IN BANGLADESH

4:45-5:00 Holson, Joseph F. INORGANIC ARSENIC AND PRENATAL DEVELOPMENT: A COMPREHENSIVE EVALUATION FOR HUMAN RISK ASSESSMENT

5:00-5:30 Panel Discussion

7:00PM HARBOR CRUISE---PRICE NOT INCLUDED IN CONFERENCE REGISTRATION FEE--$45.00 INCLUDES DINNER AND ENTERTAINMENT (It might be cool on the water, so bring a jacket or sweater.)

Presentations will be held in Pacific Room B/C.

7:00-8:00 Continental Breakfast (Pacific Foyer)

8:00-9:15 Health Effects -- Cancer Chair: Rebecca Calderon

8:00-8:15 Smith, Allan EXTRAPOLATING CANCER RISKS FOR ARSENIC IN DRINKING WATER

8:15-8:30 Bencko, V. EXPOSURE ANALYSIS IN SKIN BASALIOMA PATIENTS EXPOSED TO ARSENIC IN ENVIRONMENTAL AND OCCUPATIONAL SETTINGS

8:30-8:45 Brown, Kenneth RISK ANALYSIS OF BLADDER CANCER FROM INORGANIC ARSENIC IN DRINKING WATER IN TAIWAN

8:45-9:00 Ng, Jack TUMORS IN MICE INDUCED BY CHRONIC EXPOSURE OF HIGH CONCENTRATIONS IN DRINKING WATER

9:00-9:15 Froines, John ARSENIC INDUCED CARCINOGENESIS: A MURINE MODEL FOR THE INDUCTION OF CANCER IN METHYL-DEFICIENT C57BL/6 MICE

9:15-9:45 Panel Discussion

9:45-10:00 Break

10:00-11:15 Mechanisms Chair: Barbara Beck

10:00-10:15 Rossman, Toby G. ARSENIC AS A COMUTAGEN AND POSSIBLE COCARCINOGEN

10:15-10:30 Germolec, Dori ARSENIC ENHANCEMENT OF SKIN NEOPLASIA BY CHRONIC STIMULATION OF GROWTH-PROMOTING CYTOKINES

10:30-10:45 Snow, Elizabeth MODULATION OF DNA REPAIR AND GLUTATHIONE LEVELS IN HUMAN KERATINOCYTES BY MICROMOLAR ARSENITE

10:45-11:00 Cohen, Samuel EVALUATION OF CELL PROLIFERATIVE ACTIVITY IN THE RAT URINARY BLADDER AFTER FEEDING HIGH DOSES OF CACODYLIC ACID

11:00-11:15 Chen, TX DIFFERENCES OF PROMOTING ACTIVITY AND LOSS OF HETEROZYGOSITY BETWEEN DIMETHYLARSINIC ACID AND SODIUM L-ASCORBATE IN F1 RAT UNINARY BLADDER CARCINOGENESIS

11:15-12:00 PANEL DISCUSSION Chair: Barbara Beck

12:00-1:00 Lunch-Buffet in Hotel

1:00-2:30 Poster Session II

2:30-2:45 Break

2:45-4:30 Metabolism Chair: David Thomas

2:45-3:00 Vahter, Marie VARIATIONS IN HUMAN METABOLISM OF ARSENIC

3:00-3:15 Cebrian, Mariano PROFILE OF URINARY ARSENIC METABOLITES IN CHILDREN CHRONICALLY EXPOSED TO ARSENIC

3:15-3:30 Aposhian, H. Vasken HOW IS INORGANIC ARSENIC DETOXIFIED?

3:30-3:45 Yamauchi, Hiroshi METABOLISM OF ARSENIC AND FLUORIDE IN THE CHRONIC ARSENIC POSONING IN INNER MONGOLIA, CHINA

3:45-4:00 Carter, Dean METABOLISM OF ARSENIC AFTER PULMONARY EXPOSURE

4:00-4:15 Styblo, Miroslav METABOLISM OF ARSENIC IN CULTURED CELLS

4:15-4:30 Farago, Margaret PROPORTIONS OF URINARY ARSENIC SPECIES IN HUMAN URINE

4:30-5:00 Panel Discussion Chair: David Thomas

6:00 SEGH BUSINESS MEETING

Presentations will be held in Pacific Room B/C.

7:00-8:00 Continental Breakfast (Pacific Foyer)

8:00-9:00 Interventions and Treatment Chair: Thornton, Iain

8:00-8:15 Guha Mazumder, D.N. CHRONIC ARSENIC TOXICITY: DOSE RELATED CLINICAL EFFECT, ITS NATURAL HISTORY AND THERAPY

8:15-8:30 Kosnett, Michael J. CLINICAL APPROACHES TO THE TREATMENT OF CHRONIC ARSENIC INTOXICATION: FROM CHELATION TO CHEMOPREVENTION

8:30-8:45 Choprapawon, Chanpen HOUSEHOLD MAPPING TO ESTABLISH LONG TERM FOLLOW UP FOR CHRONIC ARSENIC POISONING IN RONPIBOOL DISTRICT, THAILAND

8:45-9:00 Quamruzzaman, Quazi EMERGENCY ARSENIC MITIGATION PROGRAM IN BANGLADESH (RAPID ACTION PROGRAM)

9:00-9:15 Anderson, Henry PUBLIC HEALTH ADVISORIES IN RESPONSE TO ARSENIC HAZARD SURVEILLANCE

9:15-9:45 PANEL DISCUSSION Chair: Thornton, Iain

9:45-10:00 Break

10:00-11:15 Treatment and Remediation Chair: Abernathy, Charles

10:00-10:15 Sancha, Ana Maria FULL-SCALE APPLICATION OF COAGULATION PROCESSES FOR ARSENIC REMOVAL IN CHILE: A SUCCESSFUL CASE STUDY

10:15-10:30 Clifford, Dennis ANION EXCHANGE PROCESSES FOR ARSENIC REMOVAL FROM WATER

10:30-10:45 Rott, Ulrich IN SITU TREATMENT OF ARSENIC IN GROUNDWATER

10:45-11:00 Hering, Janet ARSENIC OCCURRENCE AND SPECIATION IN GROUNDWATER, HANFORD, CA: IMPLICATIONS FOR HEALTH EFFECTS AND TREATMENT OPTIONS

11:00-11:45 PANEL DISCUSSION Chair: Abernathy, Charles

11:45-1:00 Lunch-Buffet in Hotel

1:00-3:00 PANEL ON DOSE RESPONSE Chair: Wixson, Bobby

1:00-1:15 Andersen, Melvin E. WILL MORE MODE OF ACTION RESEARCH IMPROVE THE ASSESSMENT OF CARCINOGENIC RISKS POSED BY ARSENIC EXPOSURE

1:15-1:30 Brown, Ken OBSERVATIONS ON EXPOSURE LEVELS AND HEALTH EFFECTS

1:30-3:00 PANEL DISCUSSION-- Andersen, Brown, Rossman, Smith, Aposhian, Cohen, Buchet

3:00 ADJOURN